EVALUATION OF ANTIOXIDANT POTENTIAL AND REDUCING POWER OF CALLUS INDUCED FROM LEAVES OF ASYSTASIA GANGETICA (L.) T.ANDERSON

Objective: Neuropathic pain arises from demage, or pathological changes in the peripheral central nervous system. The is difficult to treat as standard treatment with conventional analgesics doesn`t typically provide effective relief of pain.
 Methods: It was a one year study utilization and analysis prescriptions for PNDs (Painful neuropathic disorders). parameters evaluated were demographic profile patient (age gender), type etiology PNDs, drug data (name group drugs individual drugs, mono polytherapy, number per prescription, formulation) associated adverse reactions (ADR) prescribed drug.
 Results: Maximum patients resides age 18 – 35 y (41.2%) & more common females. most PND encountered painful diabetic neuropathy (43.9%) followed by cervical lumbar radiculopathy, postherpetic neuralgia. 2942 1020 prescriptions, out which 96.8% oral 3.2% topical formulations. Most frequently tricyclic antidepressants (27.3%) anticonvulsants (25.3%). Polypharmacy seen 89.7% compared monotherapy (10.3%). Only 132 ADRs various types seen. organ system affected gastrointestinal systems. implicated TCAs (24.4%), (16.6%), Pregabeline (9.8%). There no fatal events. Mild moderate included constipation, nausea, vomiting, drowsiness, dryness mouth.
 Conclusion: choice depends on pain, efficacy availability also ADR profile.